01of 26Dr. Meredith Grey: INRichard Cartwright/ABC via Getty; ABCWell, what wouldGrey’s Anatomybe without Ellen Pompeo’s character Dr. Meredith Grey? In a recent interview withEntertainment Weekly, Pompeo, who’s contract is only through season 16, hinted that 2020 may be her last year on the medical drama. “I’m feeling like we’re coming to the end of the stories that we’ve told and that we can tell,” she said. “I’m really excited to do some new things, it’s about time that I mix it up and I’m really excited about my producing career, and I’m definitely looking for a change.” In 2017, show creator Shonda Rhimes told E! News, “Ellen and I have a pact that I’m going to do the show as long as she’s going to do the show. So the show will exist as long as both of us want to do it. If she wants to stop, we’re stopping. So I don’t know if we’ll see 600, but I want to keep it feeling fresh.”

01of 26

Dr. Meredith Grey: IN

Richard Cartwright/ABC via Getty; ABC

ellen-pompeo

Well, what wouldGrey’s Anatomybe without Ellen Pompeo’s character Dr. Meredith Grey? In a recent interview withEntertainment Weekly, Pompeo, who’s contract is only through season 16, hinted that 2020 may be her last year on the medical drama. “I’m feeling like we’re coming to the end of the stories that we’ve told and that we can tell,” she said. “I’m really excited to do some new things, it’s about time that I mix it up and I’m really excited about my producing career, and I’m definitely looking for a change.” In 2017, show creator Shonda Rhimes told E! News, “Ellen and I have a pact that I’m going to do the show as long as she’s going to do the show. So the show will exist as long as both of us want to do it. If she wants to stop, we’re stopping. So I don’t know if we’ll see 600, but I want to keep it feeling fresh.”

02of 26Dr. Arizona Robbins: OUTABC (2)In March 2018, news broke that Jessica Capshaw, who joined the series in season 5, would not be returning for the drama’s 15th season. “For the past 10 years, I have had the rare privilege of not only playing Arizona Robbins, but also being madly in love with playing her. Arizona Robbins is kind, intelligent, funny, insightful, bold, playful, fierce and really good at her job,” Capshawtweetedin March. “She was one of the first members of the LGBTQ community to be represented in a series regular role on network television. Her impact on the world is permanent and forever. Forever,” the star said of her fan-favorite character.Deadlinereportedthat the decision for Capshaw and Sarah Drew’s exits was based strictly on the show’s creative direction. (StarEllen Pompeovigorouslydenied a reportconnecting their departures to her new $20 million salary.)

02of 26

Dr. Arizona Robbins: OUT

ABC (2)

jessica-capshaw

In March 2018, news broke that Jessica Capshaw, who joined the series in season 5, would not be returning for the drama’s 15th season. “For the past 10 years, I have had the rare privilege of not only playing Arizona Robbins, but also being madly in love with playing her. Arizona Robbins is kind, intelligent, funny, insightful, bold, playful, fierce and really good at her job,” Capshawtweetedin March. “She was one of the first members of the LGBTQ community to be represented in a series regular role on network television. Her impact on the world is permanent and forever. Forever,” the star said of her fan-favorite character.Deadlinereportedthat the decision for Capshaw and Sarah Drew’s exits was based strictly on the show’s creative direction. (StarEllen Pompeovigorouslydenied a reportconnecting their departures to her new $20 million salary.)

03of 26Dr. April Kepner: OUTEric McCandless/ABC via GettyAlong with Capshaw, Sarah Drew’s departure was announced in March 2018. Drew, who joined the show in season 6 as April Kepner, addressed the news on social media, writing, “Hey guys. Thank you for all of the love. I know you’re sad. I’m sad too. I haven’t really had the time to process this information. I’ve been with it for less than 48 hours, so I’m not ready to say my thank yous and give an all encompassing statement about my 9 years here. That will come later 🙂 For now, I’d like to say: I love you, and I love April, and her story isn’t over yet. …”

03of 26

Dr. April Kepner: OUT

Eric McCandless/ABC via Getty

greys-anatomy1

Along with Capshaw, Sarah Drew’s departure was announced in March 2018. Drew, who joined the show in season 6 as April Kepner, addressed the news on social media, writing, “Hey guys. Thank you for all of the love. I know you’re sad. I’m sad too. I haven’t really had the time to process this information. I’ve been with it for less than 48 hours, so I’m not ready to say my thank yous and give an all encompassing statement about my 9 years here. That will come later 🙂 For now, I’d like to say: I love you, and I love April, and her story isn’t over yet. …”

04of 26Paramedic Matthew Taylor: OUTEric McCandless/ABC via GettyJustin Brueing, who plays Kepner’s on-again/off-again love interest, Matthew,finallywhisked away a hopeless romantic Kepner in season 14. After reconnecting last season, the former lovers decided to make things official and tie the knot in the season finale. With Drew gone, so is Brueing.

04of 26

Paramedic Matthew Taylor: OUT

ABC’s “Grey’s Anatomy” - Season Fourteen

Justin Brueing, who plays Kepner’s on-again/off-again love interest, Matthew,finallywhisked away a hopeless romantic Kepner in season 14. After reconnecting last season, the former lovers decided to make things official and tie the knot in the season finale. With Drew gone, so is Brueing.

05of 26Dr. Link (aka “Ortho God”): INChris Carmack.Jon Kopaloff/FilmMagicBest known for his roles as Luke Ward onThe O.C.and Will Lexington onNashville,Chris Carmackis returning to ABC in his first major acting gig since the country music drama moved to CMT for its final seasons. Carmack will portray an orthopedic surgeon, nicknamed the “Ortho God.”

05of 26

Chris Carmack.Jon Kopaloff/FilmMagic

49th Annual CMA Awards - Arrivals

Best known for his roles as Luke Ward onThe O.C.and Will Lexington onNashville,Chris Carmackis returning to ABC in his first major acting gig since the country music drama moved to CMT for its final seasons. Carmack will portray an orthopedic surgeon, nicknamed the “Ortho God.”

06of 26Dr. Nico Kim: INJohn Fleenor/ABC via GettyA newbie to the cast, Alex Landi will portray Dr. Kim, the series' first gay male surgeon.

06of 26

Dr. Nico Kim: IN

John Fleenor/ABC via Getty

ABC’s “Grey’s Anatomy” - Season Fifteen

A newbie to the cast, Alex Landi will portray Dr. Kim, the series' first gay male surgeon.

07of 26

Dr. Megan Hunt: OUT

Mitch Haaseth/ABC via Getty

ABC’s “Grey’s Anatomy” - Season Fourteen

08of 26

Dr. Nathan Riggs: OUT

Vivian Zink/ABC via Getty

ABC’s “Grey’s Anatomy” - Season Twelve

09of 26Dr. Andrew DeLuca: INCould Dr. DeLuca (Giacomo Gianniotti) be Grey’s newest love interest? Accroding to the juicy season 15 trailer, it seems likely!

09of 26

Dr. Andrew DeLuca: IN

Could Dr. DeLuca (Giacomo Gianniotti) be Grey’s newest love interest? Accroding to the juicy season 15 trailer, it seems likely!

10of 26Dr. Miranda Bailey: INRichard Cartwright/ABC via Getty; ABCDr. Bailey (Chandra Wilson) has had just about enough of her Chief duties. After suffering a major heart attack in the 14th season, Bailey began to reevaluate her position at Grey Sloan Memorial. Will she give up her title?

10of 26

Dr. Miranda Bailey: IN

chandra-wilson

Dr. Bailey (Chandra Wilson) has had just about enough of her Chief duties. After suffering a major heart attack in the 14th season, Bailey began to reevaluate her position at Grey Sloan Memorial. Will she give up her title?

11of 26Dr. Ben Warren: INABC/Mitch HaasethAh, Dr. Warren! Though Warren (Jason George) left Grey Sloan to pursue his career as a firefighter, (George is currently starring inStation 19), he will continue to make appearances as Dr. Bailey’s husband.

11of 26

Dr. Ben Warren: IN

ABC/Mitch Haaseth

JASON GEORGE

Ah, Dr. Warren! Though Warren (Jason George) left Grey Sloan to pursue his career as a firefighter, (George is currently starring inStation 19), he will continue to make appearances as Dr. Bailey’s husband.

12of 26Dr. Richard Webber: INABC (2)Dr. Webber (James Pickens Jr.) is one of the few original cast members left and doesn’t seem to be going anywhere anytime soon. Thank goodness!

12of 26

Dr. Richard Webber: IN

james-pickens-jr

Dr. Webber (James Pickens Jr.) is one of the few original cast members left and doesn’t seem to be going anywhere anytime soon. Thank goodness!

13of 26Dr. Katherine Avery: INMitch Haaseth/ABCDr. Avery (Debbie Allen), Dr. Webber’s wife and Dr. Jackson Avery’s mother, loves to keep us on our toes and will continue to do so throughout the 15th season.

13of 26

Dr. Katherine Avery: IN

Mitch Haaseth/ABC

DEBBIE ALLEN

Dr. Avery (Debbie Allen), Dr. Webber’s wife and Dr. Jackson Avery’s mother, loves to keep us on our toes and will continue to do so throughout the 15th season.

14of 26Dr. Levi Schmitt: INJohn Fleenor/ABC via GettyWho can forget that brief fling Schmitt had with Jo (Camilla Luddington)?

14of 26

Dr. Levi Schmitt: IN

ABC’s “Grey’s Anatomy” - Season Fifteen

Who can forget that brief fling Schmitt had with Jo (Camilla Luddington)?

15of 26Dr. Casey Parker: INFans were introduced to Dr. Parker (Alex Blue Davis), a transgender man, in the mid-season premiere. “We worked very hard and very closely with Alex and [LGBTQ advocacy group] GLAAD on this storyline,” showrunner Krista Vernoff previously toldThe Hollywood Reporter. “The scene in which Casey disclosed to Bailey that he was a ‘proud trans man’ was rewritten more times than anything else — we wanted it exactly right… We wanted the audience to get to know this character before they knew his private medical information; we wanted his disclosure to not feel like an ‘A-ha!’ shock but a genuine unfolding of this character’s truth when he felt safe with someone.”

15of 26

Dr. Casey Parker: IN

Fans were introduced to Dr. Parker (Alex Blue Davis), a transgender man, in the mid-season premiere. “We worked very hard and very closely with Alex and [LGBTQ advocacy group] GLAAD on this storyline,” showrunner Krista Vernoff previously toldThe Hollywood Reporter. “The scene in which Casey disclosed to Bailey that he was a ‘proud trans man’ was rewritten more times than anything else — we wanted it exactly right… We wanted the audience to get to know this character before they knew his private medical information; we wanted his disclosure to not feel like an ‘A-ha!’ shock but a genuine unfolding of this character’s truth when he felt safe with someone.”

16of 26Dr. Marsh: MAYBEEric McCandless via GettyHonestly, we’re just throwing it out to the universe. What we would do to see Dr. Marsh (Scott Speedman) return and sweep Grey off her feet!

16of 26

Dr. Marsh: MAYBE

Eric McCandless via Getty

ABC’s “Grey’s Anatomy” - Season Fourteen

Honestly, we’re just throwing it out to the universe. What we would do to see Dr. Marsh (Scott Speedman) return and sweep Grey off her feet!

17of 26Dr. Teddy Altman: INGREY’S ANATOMY - “Danger Zone” - In a flashback to Iraq in 2007, the events leading up to Megan’s kidnapping are revealed. In present day, Owen and Megan hash out old wounds, on “Grey’s Anatomy,” THURSDAY, OCTOBER 26 (8:00-9:00 p.m. EDT), on The ABC Television Network. (ABC/Mitch Haaseth) MARTIN HENDERSON, KIM RAVERSo, remember when Teddy (Kim Raver) left becuase Owen couldn’t make up his mind on whether or not he wanted to be with her? Well, she’s back … and is pregnant with Owen’s child! “It’s interesting, because at the end of last year, Owen knocked on Teddy’s door and sort of like professed his love for her, and she really like fell into it,” Raver recently told PEOPLE. “I think for Teddy to let her guard down, and then to sort of feel like it wasn’t actually happening because he was just afraid of being alone, and so she kicked him out, and now she’s pregnant. So I think coming back and navigating what that’s going to be is a really interesting throughline.”

17of 26

Dr. Teddy Altman: IN

GREY’S ANATOMY - “Danger Zone” - In a flashback to Iraq in 2007, the events leading up to Megan’s kidnapping are revealed. In present day, Owen and Megan hash out old wounds, on “Grey’s Anatomy,” THURSDAY, OCTOBER 26 (8:00-9:00 p.m. EDT), on The ABC Television Network. (ABC/Mitch Haaseth) MARTIN HENDERSON, KIM RAVER

MARTIN HENDERSON, KIM RAVER

So, remember when Teddy (Kim Raver) left becuase Owen couldn’t make up his mind on whether or not he wanted to be with her? Well, she’s back … and is pregnant with Owen’s child! “It’s interesting, because at the end of last year, Owen knocked on Teddy’s door and sort of like professed his love for her, and she really like fell into it,” Raver recently told PEOPLE. “I think for Teddy to let her guard down, and then to sort of feel like it wasn’t actually happening because he was just afraid of being alone, and so she kicked him out, and now she’s pregnant. So I think coming back and navigating what that’s going to be is a really interesting throughline.”

18of 26Dr. Amelia Sheperd: INAdam Larkey/ABC via Getty; ABCSheperd (Caterina Scorsone) survived (and recovered!) from that massive tumor in her brain last season, but, what’s in store for her love life with her estranged husband, Dr. Owen Hunt? “Owen and Amelia are in basically the situation they were in at the end of last season, with more layers,” Scorsone told PEOPLE last week. “And they’ve kind of started unpacking some things from their doomed marriage, and they’ve started kind of trying to figure out like, what was brain tumor, and what was us? How do we really feel? Yeah, that’s where we are.”

18of 26

Dr. Amelia Sheperd: IN

Adam Larkey/ABC via Getty; ABC

caterina-scorsone

Sheperd (Caterina Scorsone) survived (and recovered!) from that massive tumor in her brain last season, but, what’s in store for her love life with her estranged husband, Dr. Owen Hunt? “Owen and Amelia are in basically the situation they were in at the end of last season, with more layers,” Scorsone told PEOPLE last week. “And they’ve kind of started unpacking some things from their doomed marriage, and they’ve started kind of trying to figure out like, what was brain tumor, and what was us? How do we really feel? Yeah, that’s where we are.”

19of 26

Dr. Owen Hunt: IN

Scott Garfield/ABC via Getty; Mitch Haaseth/ABC

kevin-mckidd

20of 26Dr. Alex Karev: INABC; Mitch Haaseth/ABCI mean, Karev (Justin Chambers)cannotleaveGrey’s. Ever. After a rollercoaster relationship, Karev and Jo finally tied the knot in the finale last season. We’re excited to see what’s in store for these two lovebirds!

20of 26

Dr. Alex Karev: IN

ABC; Mitch Haaseth/ABC

justin-chambers

I mean, Karev (Justin Chambers)cannotleaveGrey’s. Ever. After a rollercoaster relationship, Karev and Jo finally tied the knot in the finale last season. We’re excited to see what’s in store for these two lovebirds!

21of 26Dr. Jo Wilson (ehem, Dr. Jo Karev now!): INDanny Feld/ABC via Getty; ABCDr. Wilson (Camilla Luddington) is now officially Dr. Karev! Her happy-ever-after didn’t come easy though, thanks to her abusive estranged husband. Last season, Jo was overwhelmed when her then-husband, Dr. Paul Stadler (Matthew Morrison) paid a visit to her at Grey Sloan Memorial. After a sudden accident and one last attempt to threaten Jo, Stadler died (after Jo decided to pull the plug).

21of 26

Dr. Jo Wilson (ehem, Dr. Jo Karev now!): IN

Danny Feld/ABC via Getty; ABC

camilla-luddington

Dr. Wilson (Camilla Luddington) is now officially Dr. Karev! Her happy-ever-after didn’t come easy though, thanks to her abusive estranged husband. Last season, Jo was overwhelmed when her then-husband, Dr. Paul Stadler (Matthew Morrison) paid a visit to her at Grey Sloan Memorial. After a sudden accident and one last attempt to threaten Jo, Stadler died (after Jo decided to pull the plug).

22of 26

Dr. Paul Stadler: OUT

Richard Cartwright via Getty

ABC’s “Grey’s Anatomy” - Season Fourteen

23of 26Jenny: OUTRichard Cartwright via GettyBethanny Joy Lenz played Jenny, Jo’s crazy, abusive husband’s fiance.

23of 26

Jenny: OUT

ABC’s “Grey’s Anatomy” - Season Fourteen

Bethanny Joy Lenz played Jenny, Jo’s crazy, abusive husband’s fiance.

24of 26Thatcher Grey: INScott Garfield/ABC via GettyMeredith Grey’s father, Thatcher, will be guest-starring in the upcoming season.

24of 26

Thatcher Grey: IN

Scott Garfield/ABC via Getty

GREY S ANATOMY

Meredith Grey’s father, Thatcher, will be guest-starring in the upcoming season.

25of 26Dr. Jackson Avery: INABC; Mitch Haaseth/ABCThough we’re still shocked Kepner and Avery (Jesse Williams) didn’t end up together, we’re excited to see where his relationship with Maggie goes.

25of 26

Dr. Jackson Avery: IN

jesse-williams

Though we’re still shocked Kepner and Avery (Jesse Williams) didn’t end up together, we’re excited to see where his relationship with Maggie goes.

26of 26Dr. Maggie Pierce: INABC (2)Dr. Pierce (Kelly McCreary) is everything we wish we could be. Plus, she’s dating a stud (Dr. Avery). The end.

26of 26

Dr. Maggie Pierce: IN

kelly-mccreary

Dr. Pierce (Kelly McCreary) is everything we wish we could be. Plus, she’s dating a stud (Dr. Avery). The end.

source: people.com